全部亮點成果

儘管這場疫情帶來前所未有的衝擊，防疫科學研究中心以科學與專業築出一道防線，守護大家。未來還會出現什麼考驗不得而知，可以確定的是，每位投入防疫科學研究的工作者心中都有著一顆星，會為我們畫出滿天閃耀的星空。
https://www.youtube.com/watch?v=v5N6PCjFgWo

封城及疫苗接種，是控制新冠肺炎兩個重要的方法。在還沒有接種疫苗前，透過不同程度的封城來降低疾病的擴展速度，是不得已的選擇。 在疫苗開始施打後，雖然還沒有達到集體免疫的效果，民眾會不會因為接受了疫苗接種，對於疫情放心很多，而增加外出活動的頻率？針對這種疫苗接種後所誘發的人流（vaccination-induced mobility, VM）到底對於疫情擴散，產生多大影響，我們進行了研究。 我們以107個國家從2020年2月15日到2022年2月6日之間每天的追蹤資料，包括：民眾在零售業、娛樂場所、大眾運輸站、藥局和辦公室等不同場所的流動情況，進行了相關研究。 研究結果發現，疫苗覆蓋率每增加10個百分點，人們的流動性就會增加1.4到4.3個百分點。而在低收入國家和疫苗推廣初期，這一數字更分別高達7.9個百分點及19.2個百分點。這種增加的流動性實際上削弱了疫苗施打後控制疫情的效果。 具體來說，在休閒娛樂場所，疫苗的保護力被削弱了33.4%；在運輸站，削弱了26.4%；在日常採買場所(藥局/菜市場/超市)，削弱了15.4%。有趣的是，工作場所人流並未降低疫苗保護力。 這種現象被稱為「佩茲曼效應」(Peltzman effect)，即當人們感到更安全時，可能會採取更多風險行為。但好消息是，雖然VM削弱了疫苗的效果，但並沒有完全抵消它。因此，為了減少VM的不良影響，應該在接種疫苗後短期內減少不必要的流動；在放寬行動限制上，也許可以優先考慮工作場所與日常採買。我們的研究結果將有助於政府未來在應對疫情時，制定更為有效的人流管制政策。

公衛所梁立霖老師與醫學系吳俊穎老師有研究成果(https://pubmed.ncbi.nlm.nih.gov/37022694/)

 

莫納皮拉韋（Molnupiravir）是美國食品藥物管理署緊急授權治療新冠肺炎的藥物，但仍有許多藥物機轉尚未清楚。陽明交大傳統醫藥研究所教授蔡東湖，透過藥物動力學證實莫納皮拉韋及其活性代謝物NHC可穿透胎盤屏障進入胎兒，且可到達有效抑制病毒的濃度。這項研究發表於《刺胳針》（Lancet）系列的科學期刊《eBioMedicine》。

COVID-19疫情蔓延期間，藥物研究資訊不足。依據衛生福利部的新型冠狀病毒感染臨床處置暫行指引，處方醫師若考慮要對孕婦使用莫納皮拉韋，應確定對孕婦的效益超越風險之後才可開立，且必須向該孕婦詳細告知在懷孕期間使用藥物的風險。即使如此的風險承擔，也只是對孕婦而言，對於胎兒的治療是否達到可以治療的濃度完全未知。

蔡東湖研究團隊透過自行研發設計的微透析探針，在懷孕母鼠的血液、胎盤、羊水、胎兒中取樣，並以液相層析串聯質譜儀分析莫納皮拉韋及其有效代謝藥物的濃度。研究結果發現，母體整體血液中的有效代謝物大約有29%會到達胎兒、19%到達羊水、9%到達胎盤。再進一步結合過去體外研究文獻發現，給藥後有效代謝物通過胎盤組織進入胎兒的整體濃度，大約只有母體血液的1/3。



蔡東湖說，藥物濃度在懷孕母鼠的血液、胎盤、胎兒、以及羊水的濃度都已經高於有效治療濃度，證實這是一個有效的治療方案，服用的劑量對於懷孕母體，和胎兒都達到有效治療濃度範圍。這項科學發現，對於被COVID-19病毒感染的孕婦用藥，以及是否可以有效治療腹中胎兒感染，具有重要參考價值。

這項研究是楊慕華副校長帶領的防疫科學研究中心計劃的一部份，並與英國劍橋大學合作，成功填補了這塊有效治療孕婦及胎兒被病毒感染後用藥的拼圖。

傳醫所證實 Molnupiravir可穿透胎盤到達有效治療濃度 – 國立陽明交通大學 (nycu.edu.tw)

 

 

 

陽明交通大學微生物及免疫學研究所副教授徐嘉琳（右2）團隊和台灣大學醫學檢驗暨生物技術系教授張淑媛等人組成研究團隊，發現協助運輸細胞所需營養的轉運蛋白，卻在轉運過程中開一條通道，成為腸病毒71型等病毒入侵的缺口。

Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage. Tzu-Hau Shi, Yi-Long Huang, Chiao-Che Chen, Wen-Chieh Pi, Yu-Ling Hsu, Lee-Chiang Lo, Wei-Yi Chen, Shu-Ling Fu*, Chao-Hsiung Lin, Biochemical and Biophysical Research Communications (2020). 533(3):467-473.
Comparison of Reversal of Rat Pulmonary Fibrosis of Nintedanib, Pirfenidone and Human Umbilical Mesenchymal Stem Cells from Wharton’s Jelly. Kuo-An Chu, Chang-Ching Yeh, Fu-Hsien, Kuo, Wen-Ren Lin, Chien-Wei Hsu, Tien-Hua Chen, Yu-Show Fu. Stem Cell Research and Therapy (2020). 11; 513.
The efficacy of acupuncture for improving the side effects of COVID-19 western medicine treatments: A protocol for a systematic review and meta-analysis. Kuei-Yu Huang, Ching-Hao Chang, Chung-Hua Hsu*. Medicine (2020). 99(28):e21185.
The inhibitory effects of PGG and EGCG against the SARS-CoV-2 3C-like protease. Wei-Chung Chiou, Jui-Chieh Chen, Yun-Ti Chen, Jinn-Moon Yang, Lih-Hwa Hwang, Yi-Shuan Lyu, Hsin-Yi Yang, Cheng Huang*. Biochemical and Biophysical Research Communications (2020). [Accepted]
COVID-19 mortality is negatively associated with test number and government effectiveness. Liang LL, Tseng CH, Ho HJ, Wu CY. Scientific Reports (2020). 10(1): 12567.
Cross-Modal Contrastive Learning of Representations for Navigation using Lightweight, Low-Cost Millimeter Wave Radar for Adverse Environmental Conditions. Jui-Te Huang, Chen-Lung Lu, Po-Kai Chang, Ching-I Huang, Chao-Chun Hsu, Zu Lin Ewe, Po-Jui Huang, and Hsueh-Cheng Wang. IEEE Robotcs and Automationn Letter (2021).
Design and fabrication of cell-targeted, dual drug-loaded nanoparticles with pH-controlled drug release and near-infrared light-induced photothermal effects. Chang-Ching Weng, Tsu-An Yang, Yaw-Kuen Li. Materials and Design (2021). doi.org/10.1016/j.matdes.2020.109230.
Honeysuckle Aqueous Extracts Induced let-7a Suppress EV71 Replication and Pathogenesis In Vitro and In Vivo and Is Predicted to Inhibit SARS-CoV-2. Ying-Ray Lee, Chia-Ming Chang, Yuan-Chieh Yeh, Chi-Ying F. Huang, Feng-Mao Lin , Juan-Ting Huang, Chang-Chi Hsieh, Jen-Ren Wang and Hsiao-Sheng Liu. Viruses (2021). 13(2):308.
Uncovering Flexible Active Site Conformations of SARS-CoV-2 3CL Proteases through Protease Pharmacophore Clusters and COVID-19 Drug Repurposing. Pathak, Nikhil; Chen, Yun-Ti; Hsu, Yen-Chao; Hsu, Nung-Yu; Kuo, Chih-Jung; Tsai, Hui Ping; Kang, Jaw-Jou; Huang, Chin-Heng; Chang, Sui-Yuan; Chang, Yu-Hsiu ; Liang, Po-Huang; Yang, Jinn-Moon. ACS Nano(2021) 15, 1, 857–872.
Development of flexible electrochemical impedance spectroscopy-based biosensing platform for rapid screening of SARS-CoV-2 inhibitors. Lik-Voon, Kiew, Chia-Yu Chang, Sheng-Yu Huang, Pei-Wen Wang, Choon-Han Heh, Chung-Te Liu, Chia-Hsin Cheng, Yi-Xiang Lu, Yen-Chen Chen, Yi-Xuan Huang, Sheng-Yun Chang, Huei-Yu Tsai, Yu-An Kung, Peng-Nien Huang, Ming-Hua Hsu, Bey-Fen Leo, Yiing-Yee Foo, Chien-Hao Su, Kuo-Chen Hsu, Po-Hsun Huang, Chirk-Jenn Ng, Adeeba Kamarulzaman, Chiun-Jye Yuan, Dar-Bin Shieh, Shin-Ru Shih*, Lip-Yong Chung*, Chia-Ching Chang*. Biosensors & Bioelectronics（2021） 183/113213.
Stability of SARS-CoV-2 Spike G614 Variant Surpasses That of the D614 Variant after Cold Storage. Sheng-Yu Huang, Yu-An Kung, Peng-Nien Huang, Sheng-Yun Chang, Yu-Nong Gong, Yi-Ju Han, Huan-Jung Chiang, Kuan-Ting Liu, Kuo-Ming Lee, Chia-Yu Chang, Chia-Ching Chang, Chung-Guei Huang, Shin-Ru Shih. American Society for Microbiology (2021). 6/2/e00104-21.
COVID-19 vaccination associated with reduced mortality: evidence from cross-country quasi-experiments. Liang LL, Kuo HS, Ho HJ, Wu CY. Journal of global health (2021). 11, 05019.
Consensus statement and recommendations on the treatment of COVID-19: 2021 update. Hsin-Kuo Ko(柯信國), Wen-Kuang Yu, Sheng-Wei Pan, Wei-Chih Chen, Kuang-Yao Yang(陽光耀), Yi-Tsung Lin(林邑璁), Fu-Der Wang, Muh-Hwa Yang(楊慕華), Yuh-Min Chen(陳育民). Journal of the Chinese Medical Association (2021). [Accepted]
The efficacy and mechanism of Traditional Chinese Medicine Formula, Jing Guan Fang. Yueh-Hsin Ping, Hsin Yeh, Li-Wei Chu, Zhi-Hu Lin, Yin-Chieh Hsu, Lie-Chwen Lin, Chung-Hua Hsu, Shu-Ling Fu, Tung-Yi Lin. Frontier in Pharmacology. [Submitted]
The satisfaction of using nature herbal medicine for frontline medical staff to prevent Covid-19 in Taiwan: a retrospective clinical study. Nienyun Sharon Hsu et a., and Chung-Hua Hsu*. Journal of Herbal Medicine (2020). [Submitted]
Ugonin J acts as a SARS-CoV-2 3C-like protease inhibitor and exhibits anti-inflammatory properties. Wei-Chung Chiou, Hsu-Feng Lu, Nung-Yu Hsu, Tein-Yao Chang, Yuan-Fan Chin, Ping-Cheng Liu, Jir-Mehng Lo, Yeh B Wu, Jinn-Moon Yang and Cheng Huang*. Frontiers in Pharmacology. [Accepted]
Tannic acid-induced interfacial ligand-to-metal charge transfer and the phase transformation of Fe3O4 nanoparticles for the photothermal bacteria destruction. Chang T.-W., Ko H., Huang W.-S., Chiu Y.-C., Yang L.-X., Chia Z.-C., Chin Y.-C., Chen Y.-J., Tsai Y.-T., Hsu C.-W., Chang C.-C., Tsai P.-J., Huang C.-C. Chemical Engineering Journal (2021), 428, 131237.
Development of the sensing platform for protein tyrosine kinase activity. Wei L.-Y., Lin W., Leo B.-F., Kiew L.-V., Chang C.-C., Yuan C.-J. Biosensors (2021), 11, 240.
Facile Synthesis of Biocompatible sub-5 nm Alginate-Stabilised Gold Nanoparticles with Sonosensitising Properties. Beishenaliev A., Faruqu F. N., Leo B.F., Lit L.C., Loke Y.L., Chang C.-C., Teo Y.Y., Chik Z., Yiing Yee Foo, Chung L.Y., Kiew L.V. Colloids and Surfaces A: Physicochemical and Engineering Aspects (2021), 627, 127141.
Local ablation of gastric cancer by reconstituted apolipoprotein B lipoparticles carrying epigenetic drugs. Yang C.-L., Chao Y.-J., Wang H.-C., Hou Y.-C., Chen C. G., Chang C.-C., Shan Y.-S. Nanomedicine: Nanotechnology, Biology and Medicine (2021). [In press]
COVID-19 case doubling time associated with non-pharmaceutical interventions and vaccination: a global experience. Liang LL, Kao CT, Ho HJ, Wu CY*. J Global Health. [in press]
Modeling Scenarios of the New Lifestyle for COVID-19 Prevention in Taiwan. Mei-Lien Pan, Ting-Yu Lin, Wei Ping Goh, Jen-Hsiang Chuang, Hung-Jui Chang, Shu-Chen Tsai, Tsan-sheng Hsu, Da-Wei Wang. [Submitted]
Virus tech raises privacy concerns. Chang Liang and Wu Xiao-mi（彭松嶽指導）. Taipei Times. Sun, Aug 30, 2020.
Democracy at risk amid pandemic. Chang Liang, Wu Xiao Mi and Huang Shen（彭松嶽指導）. Taipei Times. Fri, Oct 09, 2020.
Post-modern Bizarre & Post-human Zombie in Shakespeare Contemporary Film Adaptations. 段馨君. Asian Shakespeare Association. 2020/11/5-11/7. (國外研討會論文)
From COVID-19 to Learn from Shakespeare on Pandemics: Performing Arts Living with Plague. 段馨君. 2021崑劇與莎劇國際學術研討會. (國外研討會論文)
During COVID-19 Pandemics, Reflect on Plagues in Shakespeare’s Plays. 段馨君. Interfacing 2021 @NTU. (國外研討會論文)
Asian American Playwright David Henry Hwang’s Plays and Musicals: Identity, Soft Power, and COVID-19. 段馨君. 亞美文學學術研討會. 2020/12/25. (國內研討會論文)
Playwright David Henry Hwang’s Recent Plays and Musicals: Impact of COVID- 19 on Race and Identity. Tuan, Iris H.(段馨君). Neohelicon. (A&HCI) Journal. (Springer). [Accepted]
Exploring Psychological Factors for COVID-19 Vaccination Intention in Taiwan. Lo, S. Y.（羅仕宇）, Li, S. C. S., & Wu, T. Y. 2021. Vaccines, 9(7), 764.
Research during COVID-times: Remember Performances and Singing Voice Resonate in Resilience. Tuan, Iris H.(段馨君). Aug. 5-8, 2021 in Austin, Texas. & Virtual Conference. Association for Theatre in Higher Education (ATHE). (國外研討會論文)
Digital transformation: Learning, organizational change, and the moderating roles of firm size and environmental dynamism. Chen, Ken-Zen（陳鏗任）, Seidle, R., Wang, I. K. 2021. 18th Conference of the International Joseph Schumpeter Society. (國外研討會論文)
Pop with Gods, Shakespeare, and AI: Popular Film, (Musical) Theatre, and TV Drama. Tuan, Iris H.(段馨君). ISBN: 978-981-15-7296-8. (國外專書)
COVID 19 in Taiwan: Democracy, Technology and Civil Society. Wen-Chen Chang & Chun-Yuan Lin. Book Chapter in Covid-19 in Asia: Law and Policy Contexts (edited by Victor V. Ramraj) (國外專書)
Taiwan’s Effective Pandemic Control with Dialogic Constitutionalism. Wen-Chen Chang & Chun-Yuan Lin. Routledge Handbook on Law and COVID-19 Pandemic. [Accepted] (國外專書論文)
Virofree, an Herbal Medicine-Based Formula, Interrupts the Viral Infection of Delta and Omicron Variants of SARS-CoV-2.Ly Hien Doan, Li-Wei Chu, Zi-Yi Huang, Anh Thuc Nguyen, Chia-Yin Lee, Chien-Ling Huang, Yu-Fen Chang, Wen-Yu Hsieh, Trang Thi Huyen Nguyen, Chao-Hsiung Lin, Chun-Li Su, Tsung-Hsien Chuang, Jin-Mei Lai, Feng-Sheng Wang, Chia-Jui Yang, Hui-Kang Liu*, Yueh-Hsin Ping*, Chi-Ying F. Huang.Front Pharmacol (2022),13: 905197
A Heterogeneous Unmanned Ground Vehicle and Blimp Robot Team for Search and Rescue using Data-driven Autonomy and Communication-aware Navigation.Chen-Lung Lu, Jui-Te Huang, Ching-I Huang, Zi-Yan Liu, Chao-Chun Hsu, Yu-Yen Huang, Siao-Cing Huang, Po-Kai Chang, Zu Lin Ewe, Po-Jui Huang, Po-Lin Li, Bo-Hui Wang, Lai-Sum Yim, Sheng-Wei Huang, MingSian R. Bai and Hsueh-Cheng Wang.Field Robotics (2022),2:1–38
A Houttuynia Cordata-based Chinese herbal formula improved symptoms of allergic rhinitis during the COVID-19 pandemic.Kai-Wei Chang, Tung-Yi Lin , Shu-Ling Fu , Yueh-Hsin Ping, Fang-Pey Chen, Yen-Ying Kung.Journal of the Chinese Medical Association (2022),85(6):717-722
A review of epidemic investigation on cold-chain food-mediated SARS-CoV-2 transmission and food safety consideration during COVID-19 pandemic.Lu LC, Quintela I, Lin CH, Lin TC, Lin CH, Wu VCH, Lin CS*.Journal of Food Safety (2021),41(6):e12932
Association between dissemination and characteristics of pro-/anti-COVID-19 vaccine messages on Twitter: an application of the Elaboration Likelihood Model.Vipin Saini, Li-Lin Liang, Yu-Chen Yang, Huong Mai Le, Chun-Ying Wu.JMIR Infodemiology(2022),2(1):e37077
biotransformation and transplacental transfer of the antiviral remdesivir and predominant metabolite GS-441524 article.Ling Yang, I-Hsin Lin,a Lie-Chwen Lin, Jeffrey W. Dalley,c,d and Tung-Hu Tsai.EBioMedicin,81: 104095
COVID-19-associated pulmonary aspergillosis is associated with increased in-hospital mortality and prolonged SARS-CoV-2 viral shedding.Jhong-Ru Huang , Hsiao-Chin Shen , Chuan-Yen Sun , Wei-Chih Chen, Yuh-Min Chen , Jia-Yih Feng, Kuang-Yao Yang.J Formos Med Assoc.(2022),S0929-6646(22)00279-0
Development and efficacy of lateral flow point-of-care testing devices for rapid and mass COVID-19 diagnosis by the detections of SARS-CoV-2 antigen and anti-SARS-CoV-2 antibodies.Hsieh WY, Lin CH, Lin TC, Lin CH, Chang HF, Tsai CH, Wu HT, Lin CS*.Diagnostics (2021),11(10):1760
Effect of Oral Vitamin D3 Supplementation in Exclusively Breastfed Newborns: Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.Lin CH, Lin CY, Sung YH, Li ST, Cheng BW, Weng SL, Chang SJ, Lee HC, Lee YJ, Ting WH, Chang HY, Wu YL, Lin CS*.J Bone Miner Res (2022),37(4):786-793
"GMI, a protein from Ganoderma microsporum, induces ACE2 degradation to alleviate infection of SARS-CoV-2 spike-pseudotyped virus ".Hsin Yeh, Di Ngoc Kha Vo, Zhi-Hu Lin, Ha Phan Than Ho, Wei-Jyun Hua, Wei-Lun Qiu, Ming-Han Tsai, Tung-YiLin.Phytomedicine(2022),103:154215
Honeysuckle (Lonicera japonica) and Huangqi (Astragalus membranaceus) Suppress SARS-CoV-2 Entry and COVID-19 Related Cytokine Storm in Vitro.Yuan-Chieh Yeh, Ly Hien Doan, Zi-Yi Huang, Li-Wei Chu, Tzu-Hau Shi, Ying-Ray Lee, Cheng-Tao Wu, Chao-Hsiung Lin, Shu-Tuan Chiang, Hui-Kang Liu, Tsung-Hsien Chuang, Yueh-Hsin Ping*, Hsiao-Sheng Liu* and Chi-Ying F. Huang*.Front Pharmacol (2022),12:765553
Transplacental transfer of acetaminophen in pregnant rats.Chen, J.H., Lin, I.H., Sun, C.K., Yang, L, Hsueh, T.Y., Ting, C.T., Tsai, T.H.*.Biomedicine and Pharmacotherapy (2022),154113613
Reactive Epstein–Barr Virus-Associated Hemophagocytic Lymphohistiocytosis and Thrombosis with Thrombocytopenia Syndrome following SARS-CoV-2 Vaccination and Treated with Intravenous Immunoglobin. Frontiers in Hematology.Yueh-Shih Chang, Jung-Jr Ye, Tzu-Chien Cheng, Ying-Hao Wen, Chi-Ying F. Huang*, and Kun-Yun Yeh*.Frontiers in Hematology (2022),DOI 10.3389/frhem.2022.983424
Research priorities to reduce the impact of COVID-19 in low- and middle-income countries.Polašek O, Wazny K, …, Li-Lin Liang, ..., et al (including 67 co-authors).Journal of Global Health(2022),12/09003
The ORF8 Protein of SARS-CoV-2 Modulates the Spike Protein and Its Implications in Viral Transmission.Jen-Mei Chou, Jo-Ling Tsai, Jo-Ning Hung, I-Hua Chen, Szu-Ting Chen and Ming-Han Tsai.Front. Microbiol(2022),13:883597
The selection of COVID-19 vaccines by Taiwanese university students based on the theory of integrated planning behavior.Po-Chun Lee*, Ching-Yuan Huang, Li-Lin Liang, Min-Hsin Huang, Meng-Jun Hsu.Human Vaccines & Immunotherapeutics(2022),22:2148500
Trust, Democracy, and Hygiene Theatre: Taiwan’s Evasion of the Pandemic.Robert B Leflar.Asian Journal of Law and Society (2022), 1–12 doi:10.1017/als.2022.19
WFH-VR: Teleoperating a Robot Arm to set a Dining Table across the Globe via Virtual Reality.L.-S. Yim, Quang TN Vo, C.-I. Huang, C.-R. Wang, Wren McQueary H.-C. Wang*, Haikun Huang, and L.-F. Yu.IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2022)
公共行政與治理的共同演變：審議的轉向與價值共創.范玫芳.
臺灣COVID-19疫情流行之超額死亡估計.孔常喜、殷君豪、梁立霖.2022年公共衛生聯合年會暨學術研討會.
數位防疫的知異行難.彭松嶽、潘美玲、范玫芳、陳盈羽、蔡欣怡.
從公共危機到國家安全意識－美國醫療對應措施立法之演進與分析.施明遠.月旦法學(2021)312期
電子圍籬作為拘禁措施與提審案件之審查範圍 評臺灣臺北地方法院 111 年度行提字第 2 號與第 3 號裁定.劉青峰.交大法學評論(2022).第十三期（2022年秋季號）
大疫當前－從生技製藥產業鏈食物解析我國藥品研究實驗與試驗免責的範圍與界限. 李秉燊、劉汗曦（楊秀儀副教授指導）. 律師通訊（2020）. 全國律師月刊2020年12月號.
運算都市生活：數據實踐與日常生活的轉化. 彭松嶽. 新聞學研究（2020）.
台灣汽車零組件的技術擴散與產業升級. 劉清耿. 台灣社會學(2021), 第40期.
新冠肺炎疫苗的分配正義：台灣疫苗分配模式之分析. 楊元傑、林映彤、嚴如玉. 北市醫學雜誌 2021.3.
COVID-19與國際人權. 張文貞. 月旦法學期刊 2021 年 5 月.
曙光之外 美國疫苗研發的啟示. 楊秀儀. 蘋果日報.
防疫共同體的物資整備──從我國口罩光榮動員經驗看下一波超前部署所需要的法制整備. 雷文玫. 月旦法學期刊2021年5月.
台須因抗疫擋下國外表藝團體嗎. 段馨君. 蘋果日報論壇版政策建言, 2020/12/8.
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作者：國立陽明交通大學防疫科學暨健康一體研究中心團隊。編者：郭旭崧、楊慕華。出版日期： 2022年06月24日

由陽明交大傳統醫藥研究所開發的中藥「淨冠方」被證實可降低、減輕新冠肺炎相關症狀，可作為接種疫苗後另一層輔助及減毒防護

1. 此平台找到蛋白酶活性位點的重要動態結合機制進行藥物篩選。同時更發現另一個 JMY206 細胞實驗降低病毒能力比瑞德西韋強數十倍之 FDA 老藥且為多功效抗新冠藥，可同時阻擋新冠入侵、抑制新冠複製及降低免疫風暴。
2. 本研究已提供細胞和動物實驗數據，並建立其抗發炎作用機轉。

1. 結合血氧量測設備，透過5G手機高通量與APP介面等雲端系統回報健康資訊與醫療端進行資訊串連及時判讀，進行血氧趨勢分析與異常通報警示技術，以達到即時監測及醫療功能。
2. 有不錯的臨床數據，目前已於新北市立聯合醫院、陽明交大附設醫院上線，經過初步實證確實能夠提早監測到病患血氧變化並施以治療。

2019年新型冠状病毒肺炎(COVID-19使患者的肺部功能重受損·以及免疫系統的失調,使促炎細胞因子大量被釋放,進而產生「細胞激素風暴」,其可導致致死的急性呼吸窘迫症候群(ARDS)。 其餘的COVID-19的倖存者將面臨不可逆的纖維化肺部疾病和終生残疾。我們建立了一個針對COVID-19的藥物篩選平台,研究與其他呼吸道病毒(MERS-CoV和SARS-CoV)相比,老藥是否能轉COVID-19的獨特特徵。基因集富集分析(GSEA)表明,以黃耆為主的傳統中藥配方一YQ1,可以逆轉SARS-CoV-2的感染特徵並抑制細胞因子風暴,從而抑制ARDS的產生。生化研究表明,YQ1可以作為let-7a、miR-148a/b和miR-146a的刺激物,進而抑制病毒複製及抑制促炎症細胞因子的釋放並促進巨噬細胞極化為抗病毒的M1表型,同時控制細胞內部氧化壓力,以及有效調節促炎細胞因子的分泌。YQ1在治療博萊徽素誘導的ARDS和防止ARDS進展的大鼠模型中也展現出其有效姓。實驗大鼠的動脈血氧飽和度、呼吸頻率、肺部形態得到顯著改善·最後,YQ1已被藥品仿單標示外使用治療21名長庚醫院住院的COVID-19患者·其中包括3名ARDS患者·且他們都已出院。這表明我們的新創研發及其所帶來的價值和效益為(1)獨有的預測平台系統可以為COVID-19患者以及未來的流行病優先篩選老藥(2)YQ1是一種非常有潛力的預防和早期干治療COVID-19的藥物。

新冠肺炎(COVID19)為全球流行之嚴重特殊傳染性肺炎,全球已累計逾1.93億確診個案·其中逾415.6萬人死亡,是人類歷史上大規模流行病一。由於國外疫苗研成功，加上快篩與PCR檢測技術方面成熟,國内衛福部目前也安排國人接種新冠肺炎疫苗,因此未来科技防疫將是未來預防新冠疫情防治扮演極為重要的角色。

技術簡介:

新型冠狀病毒藉由與人類細胞的ACE2受體結合感染細胞。本技術以新穎鈀薄膜電化學阻抗偵測系統為基礎，研發出新型冠狀病毒偵測平台並可用於篩選抑制新型冠狀病毒感染藥物，只需要取樣1微升(μL)的樣品，就能在21分鐘內偵測辨識新型冠狀病毒或ACE2抑制劑。




科學突破性:

本技術開發之病毒棘蛋白與ACE2交互作用電化學感測平台，可比較不同病毒變異株對人類ACE2作用之差異，亦可篩選抑制病毒藥物或分子，這是傳統PCR或抗原抗體對檢測方法無法比擬的。為前所未有新穎發現。鈀電極有特殊表面結構，可與蛋白質直接接合。只需取樣1微升，能在21分鐘內偵測辨識ACEi對病毒抑制效果。




產業應用性:

本抗感測平台，以具表面活性之鈀奈米薄膜電極為基礎，蛋白質可直接接合在鈀電極，取樣1微升, 4g以下的藥物，能在21分鐘內偵測辨識藥物對病毒的抑制效果。亦可感測疫苗中和抗體等效滴度，對未來確認疫苗接種成效，及對不同變異株之保護力極有助益。亦可用於癌症或其他具急迫性、感染性疾病之感測及抑制藥物之篩選。




媒合需求:

1.欲媒合之產業領域：電子與光電、材料化工、生技醫藥、生活應用。2.欲媒合項目：技術轉移、生產製造、投資合作。