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COVID-19疫情帶給世界經濟、民生及醫藥衛生等全面性的衝擊，也帶來了新興的趨勢與契機..本校防疫科學暨健康一體研究中心於1/20(六)舉辦「COVID-19後疫情展望新趨勢研討會」，將深入了解進入後疫情時代的我們，該如何透過跨領域的合作，探索未來的發展趨勢，在下一次疫情來臨前占得先機! 歡迎各位老師與同學共襄盛舉!

為培訓高防護實驗室人才，提升國家研究檢驗量能，陽明交大與台北榮總合作，邀請國防醫學院預防醫學研究所高防護實驗室專家團隊，於7月11日至13日，在台北榮總生物安全第3等級實驗室開設「高防護實驗室人才培訓專班」，共有陽明交大師生與台北榮總檢驗人員共6名學員參加。課程涵蓋生物安全管理組織及運作、感染性生物材料管理法規、生物風險管理，及個人防護具實作和BSL-3實驗室儀器使用等議題，並進行意見雙向回饋、綜合討論與考試，提升學員生物安全管理和個人防護能力。

原文網址: 國家檢驗量能再升級！陽明交大與台北榮總首度合作培訓高防護實驗室人才 新聞 https://newtalk.tw/news/view/2023-07-21/880722
 

陽明交通大學微生物及免疫學研究所副教授徐嘉琳（右2）團隊和台灣大學醫學檢驗暨生物技術系教授張淑媛等人組成研究團隊，發現協助運輸細胞所需營養的轉運蛋白，卻在轉運過程中開一條通道，成為腸病毒71型等病毒入侵的缺口。

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to pose threats to public health. The clinical manifestations of lung pathology in COVID-19 patients include sustained inflammation and pulmonary fibrosis. The macrocyclic diterpenoid ovatodiolide (OVA) has been reported to have anti-inflammatory, anti-cancer, anti-allergic, and analgesic activities. Here, we investigated the pharmacological mechanism of OVA in suppressing SARS-CoV-2 infection and pulmonary fibrosis in vitro and in vivo. Our results revealed that OVA was an effective SARS-CoV-2 3CLpro inhibitor and showed remarkable inhibitory activity against SARS-CoV-2 infection. On the other hand, OVA ameliorated pulmonary fibrosis in bleomycin (BLM)-induced mice, reducing inflammatory cell infiltration and collagen deposition in the lung. OVA decreased the levels of pulmonary hydroxyproline and myeloperoxidase, as well as lung and serum TNF-ɑ, IL-1β, IL-6, and TGF-β in BLM-induced pulmonary fibrotic mice. Meanwhile, OVA reduced the migration and fibroblast-to-myofibroblast conversion of TGF-β1-induced fibrotic human lung fibroblasts. Consistently, OVA downregulated TGF-β/TβRs signaling. In computational analysis, OVA resembles the chemical structures of the kinase inhibitors TβRI and TβRII and was shown to interact with the key pharmacophores and putative ATP-binding domains of TβRI and TβRII, showing the potential of OVA as an inhibitor of TβRI and TβRII kinase. In conclusion, the dual function of OVA highlights its potential for not only fighting SARS-CoV-2 infection but also managing injury-induced pulmonary fibrosis.

團隊過去已證實，GMI 可透過預防 SARS-CoV-2 感染，例如誘導宿主細胞的 ACE2 降解、抑制細胞融合以及消除 ACE2 與刺突蛋白的結合，本次研究更確定了 GMI 在 SARS-CoV-2 感染中的抗炎作用與機制。團隊量小鼠巨噬細胞和肺組織中 SARS-CoV-2 亞基引起的炎症，並以動物實驗證實 GMI 可抑制 SARS-CoV-2 相關炎症及其抑制機轉。

當發生疫情時，基礎研究能幫上甚麼忙? 以生物感測研究用於病毒篩檢及抗病毒感染藥物篩選為例

全文詳見物理雙月刊NO.45中文版 2023年4月 第二期 第9頁-第16頁



資訊來源：博客來  https://www.books.com.tw/products/R030093542?loc=P_0004_001


 

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